英語原著論文
- Afrin W, Furuya S, Yamamoto K. Characterization of a glutamate-cysteine
ligase in Bombyx mori. (2023) Mol Biol Rep, https://doi.org/10.1007/s11033-022-08191-6.
- Furuya S, Fukuwatari T. (2022) Physiological Functions of Proteinogenic Amino Acid. J. Nutr. Sci. Vitaminol. (Tokyo), 68, 528-530.
- Hamano M, Esaki K, Moriyasu K, Yasuda T, Mohri S, Tashiro K, Hirabayashi Y, Furuya S. (2021) Hepatocyte-Specific Phgdh-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation. Nutrients, 13, 3468; https://doi.org/10.3390/nu13103468.
- Shen W, Lee S-R, Mathai AE, Zhang R, Du J, Yam MX, Pye V, Barnett NL, Rayner CL, Zhu L, Hurley JB, Seth P, Hirabayashi Y, Furuya S, Gillies MC (2021) Effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health. Glia, 69, 1966-1986, https://doi.org/10.1002/glia.24005.
- Hamano M, Tomonaga S, Osaki Y, Oda H, Kato H, Furuya S. (2020) Transcriptional activation of Chac1 and other Atf4-target genes induced by extracellular L-serine depletion is negated with glycine consumption in Hepa1-6 hepatocarcinoma cells. Nutrients, 12, 3018; doi:10.3390/nu12103018.
- Yamamoto K, Mohri S, Furuya S. (2020) D-3-Phosphoglycerate dehydrogenase from the silkworm Bombyx mori: Identification, functional characterization, and expression. Arch. Insect Biochem. Physiol., Oct 14:e21751. doi: 10.1002/arch.21751.
- Le Douce J, Maugard M, Veran J, Matos M, Jégo P, Vigneron PA, Faivre E, Toussay X, Vandenberghe M, Balbastre Y, Piquet J, Guiot E, Tran NT, Taverna M, Marinesco S, Koyanagi A, Furuya S, Gaudin-Guérif M, Goutal S, Ghettas A, Pruvost A, Bemelmans AP, Gaillard MC, Cambon K, Stimmer L, Sazdovitch V, Duyckaerts C, Knott G, Hérard AS, Delzescaux T, Hantraye P, Brouillet E, Cauli B, Oliet SHR, Panatier A, Bonvento G. (2020) Impairment of glycolysis-derived L-serine production in astrocytes contributes to cognitive deficits in Alzheimer's disease. Cell Metab., 31, 503-517. e8 2020 Mar 3. doi: 10.1016/j.cmet.2020.02.004.
- Ichinose T, Murasawa H, Ishijima T, Okada S, Abe K, Matsumoto S, Matsui T, Furuya S. (2020) Tyr-Trp administration facilitates brain norepinephrine metabolism and ameliorates a short-term memory deficit in a mouse model of Alzheimer’s disease. PLoS One. 15, e0232233. doi: 10.1371/journal.pone.0232233. eCollection 2020.
- Kawano Y, Yating H, Sasaki M, Furuya S. (2019) Silk sericin intake leads to increases in L-serine and L-tyrosine levels in the mouse brain and the simultaneous facilitation of brain noradrenergic turnover. Biosci. Biotech. Biochem. 84, 372-379. doi: 10.1080/09168451.2019.1676693.
- Haque MR, Hirowatari A, Nai N, Furuya S, Yamamoto K. (2019) Serine hydroxymethyltransferase from the silkworm Bombyx mori: Identification, distribution, and biochemical characterization. Arch. Insect Biochem. Physiol. e21594. doi: 10.1002/arch.21594.
- Haque MR, Hirowatari A, Saruta F, Furuya S, Yamamoto K. (2019) Molecular survey of the phosphoserine phosphatase involved in L-serine synthesis by silkworms (Bombyx mori). Insect Mol. Biol. doi: 10.1111/imb.12609.
- Haque MR, Hirowatari A, Koyanagi A, Ichinose T, Abiru M, Mohri S, Furuya S, Yamamoto K. (2019) Molecular characterization and expression analysis of a phosphoserine aminotransferase involving L-serine synthesis from silkworm, Bombyx mori. Arch Insect Biochem Physiol. e21553. doi: 10.1002/arch.21553.
- Haque MR, Higashiura A, Nakagawa A, Hirowatari A, Furuya S, Yamamoto K. (2019) Molecular structure of a 5,10-methylenetetrahydrofolate dehydrogenase from the silkworm Bombyx mori. FEBS Open Bio. 9, 618-628. doi: 10.1002/2211-5463.12595.
- Koshimizu H, Hirata N, Takao K, Toyama K, Ichinose T, Furuya S, Miyakawa T. (2019) Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacol Rep. 39, 56-60. doi: 10.1002/npr2.12041.
- Hino, Y., Koyanagi, A., Maebuchi, M., Ichinose, T., Furuya, S. (2018) Comparison of the effect of soy and casein-derived peptide administration on tyrosine and catecholamine metabolism in the mouse brain. J. Nutr. Sci. Vitaminol. (Tokyo) 64, in press.
- Vandekeere, S., Dubois, C., Kalucka, J., Sullivan, M.R., García-Caballero, M., Goveia, J., Chen, R., Diehl, F.F., Bar-Lev, L., Souffreau, J., Pircher, A., Kumar, S., Vinckier, S., Hirabayashi, Y., Furuya, S., Schoonjans, L., Eelen, G., Ghesquière, B., Keshet, E., Li, X., Vander Heiden, M.G., Dewerchin, M., Carmeliet, P. (2018) Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. Cell Metab. 28, 573-587.e13. doi: 10.1016/j.cmet.2018.06.009.
- Hamano, M., Haraguchi, Y., Sayano, T., Zyano, C., Arimoto, Y., Kawano, Y., Moriyasu, K., Udono, M., Katakura, Y., Ogawa, T., Kato, H. and Furuya, S. (2018) Enhanced vulnerability to oxidative stress and induction of inflammatory gene exprssion in 3-phosphoglycerate dehydrogenase-deficient fibroblasts. FEBS Open Bio. doi.org/10.1002/2211-5463.12429
- Takai, Y., Kawai,M., Ogo, T., Ichinose, T., Furuya, S., Takaki, N., Tone, Y., Udo, H., Furuse, M., Yasuo, S. (2018) Early-life photoperiod influences depression-like behavior, prepulse inhibition of the acoustic startle response, and hippocampal astrogenesis in mice. Neuroscience 374, 133-143. doi: 10.1016/j.neuroscience.2018.01.038
- Imai, H., Moriyasu, K., Nakahata, A., Maebuchi, M., Ichinose, T., Furuya, S. (2017) Soy peptide ingestion ingestion augments the synthesis and metabolism of noradrenaline in the mouse brain. Biosci. Biotech. Biochem. 81, 1007-1013
- Fukano, Y., Okino, N., Furuya, S., Ito, M. (2016) A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration. Biochemical and Biophysical Research Communications, 478, 624-630.
- Hamano, M., Sayano, T., Kusada, W, Kato, H., Furuya, S. (2016) Microarray data on altered transcriptional program of Phgdh-deficient mouse embryonic fibroblasts caused by L-serine depletion. Data in Brief. 7, 1598–1601 (doi:10.1016/j.dib.2016.04.052)
- Sayano, T., Kawano, Y., Kusada, W., Arimoto, Y., Esaki, K., Hamano, M., Udono, M., Katakura, Y., Ogawa, Y., Kato, H., Hirabayashi, Y., Furuya, S. (2016) Adaptive response to L-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts. FEBS Open Bio. doi: 10.1002/2211-5463.12038
- Moriyasu, K., Ichinose, T., Nakahata, A., Tanaka, M., Matsui, T., Furuya, S. (2016) The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem. Int. J. Pept. vol. 2016, Article ID 6020786, 5 pages. doi:10.1155/2016/6020786
- Esaki, K., Sayano, T., Sonoda, C., Akagi, T., Suzuki, T., Ogawa, T., Okamoto, M., Yoshikawa, T., Hirabayashi, Y., Furuya, S. (2015) L-Serine deficiency elicits intracellular accumulation of cytotoxic deoxy-sphingolipids and lipid body formation. J. Biol. Chem. 290, 14595-14609.
- Ichinose, T., Moriyasu, K., Nakahata, A., Tanaka, M., Matsui, T., Furuya, S. (2015) Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain. Biosci. Biotech. Biochem. 79, 1542-1547.
- Ehmsen, J.T., Ma, T.M., Sason, H., Rosenberg, D., Ogo, T., Furuya, S., Snyder, S.H., Wolosker, H. (2013) D-Serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase. J. Neurosci. 33, 12464-12469.
- Sayano, T., Kawakami, Y., Kusada, W., Suzuki, T., Kawano, Y., Watanabe, M., Takashima, K., Arimoto, Y., Esaki, K., Wada, A., Yoshizawa, F., Watanabe, M., Okamoto, M., Hirabayashi, Y., Furuya, S. (2013) Serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the central nervous system. FEBS J. 280, 1502-1517.
- Takao, K., Kobayashi, K., Hagihara, H., Ohira, K., Shoji, H., Hattori, S., Koshimizu, H., Umemori, J., Toyama, K., Nakamura, H.K., Kuroiwa, M., Maeda, J., Atsuzawa, K., Esaki, K., Yamaguchi, S., Furuya, S., Takagi, T., Walton, N.M., Hayashi, N., Suzuki, H., Higuchi, M., Usuda, N., Suhara, T., Nishi, A., Matsumoto, M., Ishii, S., Miyakawa, T. (2013) Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38, 1409-1425.
- Esaki, K., Ohmori, T., Maebuchi, M., Nakamori, T., Ohshima, T., Furuya, S. (2013) Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY. Biosci. Biotech. Biochem. 77, 847-849.
- Suzuki, M., Sasabe, J., Furuya, S., Hamase, K., Aiso, S. (2012) Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection. Brain Res. 1466, 167-176.
- Esaki, K., Kokido, T., Ohmori, T., Tsukino, M., Ohshima, T., Furuya, S. (2011) Soy peptide ingestion increases neuroactive amino acids in the adult brain of wild-type and genetically engineered serine-deficient mice. J. Nutr. Food Sci. 1, 109. doi:?10.4172/2155-9600.100010
- Yang, JH., Wada, A., Yoshida, K., Miyoshi, Y., Sayano, T., Esaki, K., Kinoshita, O.M., Tomonaga, S., Azuma, N., Watanabe, M., Hamase, K., Zaitsu, K., Machida, T., Messing, A., Itohara, S., Hirabayashi, Y., Furuya, S. (2010) Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an NMDA receptor co-agonist, in adult brain. J. Biol. Chem. 285, 41380-41390.
- Kinoshita, O.M., Shinoda, Y., Sakai, K., Hashikawa, T., Watanabe, M., Machida, T., Hirabayashi, Y., Furuya, S. (2009) Selective up-regulation of 3-phosphoglycerate dehydrogenase (Phgdh) expression in adult subventricular zone neurogenic niche. Neurosci. Lett. 453, 21-26.
- Kinoshita, O.M., Furuya, S., Ito, S., Shinoda, Y., Yamazaki, Y., Greimel, P., Ito, Y., Hashikawa, T., Machida, T., Nagatsuka, Y., Hirabayashi, Y. (2009) Lipid rafts enriched in phosphatidylglucoside direct astroglial differentiation by regulating tyrosine kinase activity of EGF receptors. Biochem. J. 419, 565-575.
- Kawakami, Y., Yoshida, K., Yang, J.H., Suzuki, T., Azuma, N., Tanaka, H., Watanabe, M., Kuhara, S., Hirabayashi, Y., Furuya, S. (2009) Impaired neurogenesis in the embryonic spinal cord of Phgdh knockout mouse, a serine deficiency disorder model. Neurosci. Res. 63, 184-193.
- Furuya, S., Yoshida, K., Kawakami,Y., Yang, J-H., Sayano, T., Azuma, N., Tanaka, H., Kuhara, S., Hirabayashi, Y. (2008) Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: Changes in gene expression and associated regulatory networks resulting from serine deficiency. Funct. Integr. Genomics. 8, 235-249.
- Satoi, H., Tomimoto, H., Ohtani, R., Kitano, T., Kondo, T., Watanabe, M., Oka, N, Akiguchi, I., Furuya, S., Hirabayashi, Y. Okazaki, T. (2005) Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis. Neuroscience 130, 657-666.
- Shimizu, M., Furuya, S., Shinoda, Y., Mitoma, J., Okamura, T., Miyoshi, I., Kasai, N., Hirabayashi, Y., and Suzuki, Y. (2004) Functional analysis of mouse 3-phosphoglycerate dehydrogenase (Phgdh) gene promoter in developing brain. J. Neurosci. Res. 76, 623-632.
- Mitoma, J., Furuya, S., Shimizu, M., Shinoda, Y., Yoshida, K., Azuma, N., Tanaka, H., Suzuki, Y., Hirabayashi, Y. (2004) Mouse 3-phosphoglycerate dehydrogenase gene: Genomic organization, chromosomal localization, and promoter analysis. Gene 334, 15-22.
- Yamamoto, T., Nishizaki, I., Nukada, T., Kamegaya, E., Furuya, S., Hirabayashi, Y., Ikeda, K., Hata, H., Kobayashi, H., Sora, I., Yamamoto, H. (2004) Functional identification of ASCT1 neutral amino acid transporter as the predominant system for the uptake of L-serine in rat neurons in primary culture. Neurosci Res. 49, 101-111.
- Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., and Hirabayashi, Y. (2004) Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. J. Biol. Chem. 279, 3573-3577.
- Yamashita, N., Sakai, K., Furuya, S., Watanabe, M. (2003) Selective expression of L-serine synthetic enzyme 3PGDH in Schwann cells, perineuronal glia and endoneurial fibroblasts in rat sciatic nerves and its upregulation after crush injury. Arch. Histol. Cytol. 66, 429-436.
- Chen, P., Peng, C., Luff, J., Spring, K., Watters, D., Bottle, S., Fururya, S., Lavin, M.F. (2003) Oxidative stress is responsible for deficient survival and dendritogenesis in Purkinje neurons from Atm mutant mice. J. Neurosci. 23, 11453-11460.
- Furuya, S. and Watanabe, M. Novel Neuroglial and Glioglial Relationships Mediated by L-Serine Metabolism. Arch. Histol. Cytol. 66, 109-121 (2003).
- Chen, N., Furuya, S., Shinoda, Y., Yumoto, M., Ohtake, A., Sato, K., Doi, H., Hashimoto, Y., Kudo, Y., Higashi, H. (2003) Extracellular carbohydrate-signal triggering PKA-dependent neuronal actin-reorganization. Neuroscience 122, 985-995.
- Yamamoto, T., Nishizaki. I, Furuya, S., Hirabayashi, Y., Takahashi, K., Okuyama, S., Yamamoto, H. (2003) Characterization of rapid and high-affinity uptake of L-serine in neurons and astrocytes in primary culture. FEBS Lett. 548, 69-73.
- Chen, N., Furuya, S., Doi, H., Hashimoto, Y., Kudo, Y., Higashi, H. (2003) Ganglioside/Calmodulin kinase II signal inducing cdc42-mediated neuronal actin-reorganization. Neuroscience 120, 163-176.
- Sakai, K., Shimizu, K., Koike, T., Furuya, S, Watanabe, M. (2003) Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J. Neurosci., 23, 550-560.
- Yamasaki, M., Yamada, K., Furuya, S, Mitoma, J., Hirabayashi, Y., Watanabe M. (2001) 3-Phosphoglycerate dehydrogenase (3PGDH), a key enzyme for L-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain. J. Neurosci. 21, 7691-7704.
- Hartell, N.A., Furuya, S., Jacoby, S., Okada, D. (2001) Intercellular action of nitric oxide increases cyclic GMP in cerebellar Purkinje cells. Neuroreport 12, 25-28.
- Sugishita, H., Kuwabara Y., Toku K., Doi L., Yang L., Mitoma J., Furuya S., Hirabayashi Y., Maeda N., Sakanaka M., Tanaka J. (2001) L-Serine regulates the activities of microglial cells that express very low level of 3-phosphoglycerate dehydrogenase, an enzyme for L-serine biosynthesis. J. Neurosci. Res., 64, 392-401.
- Furuya, S., Tabata, T., Mitoma, J., Yamada, K., Yamasaki, M., Makino, A., Yamamoto, T., Watanabe, M., Kano, M., Hirabayashi, Y. (2000) L-Serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons. Proc. Natl. Acad. Sci. USA 97, 11528-11533.
- Furuya S, Fukuwatari T. (2022) Physiological Functions of Proteinogenic Amino Acid. J. Nutr. Sci. Vitaminol. (Tokyo), 68, 528-530.
総説
- 古屋 茂樹,佐矢野 智子,江崎 加代子 (2014) 個体発生と高次機能制御におけるde novoセリン合成の必須性. 特集「アミノ酸機能のニューパラダイム」,生化学,
14, 372-381.
- 古屋 茂樹 (2012) 3-ホスホグリセリン酸脱水素酵素欠損症. 別冊 日本臨牀 新領域別症候群シリーズ No.19「先天代謝異常症候群(第2版)ー病因・病態研究,診断・治療の進歩ー」,pp327-331.
- 古屋 茂樹 (2012) ホスホセリンアミノトランスフェラーゼ欠損症. 別冊 日本臨牀 新領域別症候群シリーズ No.19「先天代謝異常症候群(第2版)ー病因・病態研究,診断・治療の進歩ー」,pp332-334.
- 古屋 茂樹 (2012) ホスホセリンホスファターゼ欠損症. 別冊 日本臨牀 新領域別症候群シリーズ No.19「先天代謝異常症候群(第2版)ー病因・病態研究,診断・治療の進歩ー」,pp335-337.
- 古屋 茂樹 (2011) セリン合成不全によるスフィンゴ脂質恒常性破綻と末梢神経障害・糖尿病関連病態. アミノ酸研究,5, 15-20.
- 古屋 茂樹 (2010) アミノ酸研究の最前線I. 「外科と代謝・栄養」, 44, 65-71.
- 加藤 久典, 林 裕造, 高橋 迪雄, 古屋 茂樹, 岸 恭一, 門脇 基二 (2007) 進化の視点からアミノ酸栄養を考える (論壇). 日本栄養・食糧学会誌, 60, 151-166.
- 古屋 茂樹 (2006) セリン:脳を育むアミノ酸. 必須アミノ酸研究 (Report of the Research Committee of Essential Amino Acids), 177, 20-27.
- 古屋 茂樹 (2006) セリンは神経細胞の必須アミノ酸である. 「バイオサイエンスとインダストリー」, 64, 27-29.
- Furuya, S. (2008) An essential role for de novo synthesis of L-serine in CNS development. Asia Pac. J. Clin. Nutr. 17 (S1), 307-310.
- Hirabayashi, Y., Furuya, S. (2008) Roles of L-serine and sphingolipid synthesis in brain development and neuronal survival. Prog. Lipid Res. 47, 188-203.
- Furuya, S. and Watanabe, M. (2003) Novel neuroglial and glioglial relationships mediated by L-serine metabolism. Arch. Histol. Cytol. 66, 109-121.
- 古屋 茂樹 (2012) 3-ホスホグリセリン酸脱水素酵素欠損症. 別冊 日本臨牀 新領域別症候群シリーズ No.19「先天代謝異常症候群(第2版)ー病因・病態研究,診断・治療の進歩ー」,pp327-331.
出版物
- 古屋 茂樹 (2007) 第4章 脳機能とセリン合成, 「アミノ酸の機能特性 -ライフサイエンスにおける新しい波-」, 日本栄養・食糧学会監修、矢ケ崎一三・門脇基二・舛重正一・横越英彦編集,
建帛社, pp135-169 (2007).
- 古屋 茂樹, 吉田 一之, 平林 義雄 (2006) III編 発現解析と機能解析, 第1章モデル動物 4.マウス, 「DNAチップ活用テクノロジーと応用」, 久原哲編, CMC出版, pp118-130.
- 古屋 茂樹 (2002) グリア細胞による脳の発達支持機構, 脳・神経科学入門講座(下)、第1章 脳の発生と発達6、渡辺雅彦編、羊土社、分担執筆、pp88-101.
- 古屋 茂樹, 吉田 一之, 平林 義雄 (2006) III編 発現解析と機能解析, 第1章モデル動物 4.マウス, 「DNAチップ活用テクノロジーと応用」, 久原哲編, CMC出版, pp118-130.
研究報告
- 古屋 茂樹,江崎 加代子 (2012) 大豆たん白質由来ジペプチドが中枢神経系に及ぼす作用の神経化学的評価,「大豆たん白質研究」, 15, 79-84.
- 古屋 茂樹 (2010) 遺伝性セリン合成不全疾患モデルマウスの脳内遊離アミノ酸組成に及ぼす大豆ペプチド摂取効果の定量的検討, 「大豆たん白質研究」, 13, 109-115.