業績目録（平成２１年１月１５日現在） 　 岡本　正宏 T. 原著論文 Ａ．代謝制御・酵素反応制御にかかわる生物情報学的研究 1. "Note on Steady-state Approximation of Enzyme Kinetics", J. Fac. Agr., Kyushu Univ., 19, 125 - 138 (1975), Masahiro Okamoto, Yoichi Aso, Daizo Koga, Katsuya Hayashi. 2. "Studies on the Threshold Mechanism of Enzymatic Reaction", J. Fac. Agr., Kyushu Univ., 20, 87 - 95 (1976), Kaoru Okuyama, Masahiro Okamoto, Yoichi Aso, Katsuya Hayashi. 3. "Oscillatory Behavior of Enzymatic Feedback System", J. Fac. Agr., Kyushu Univ., 20, 105 - 116 (1976), Masahiro Okamoto, Yoichi Aso, Katsuya Hayashi. 4. "On the Saturation of the Threshold-type Response in Enzymatic Reaction System", J. Fac. Agr., Kyushu Univ., 21, 67 - 77 (1977), Kaoru Okuyama, Masahiro Okamoto, Katsuya Hayashi. 5. "Response of Enzymatic Feedback System to Oscillatory Input", J. Fac. Agr., Kyushu Univ., 22, 15 - 24 (1977), Masahiro Okamoto, Yoichi Aso, Katsuya Hayashi. 6. "Threshold of Enzymatic Reaction System, Further Studies with a Simplified Model", J. Fac. Agr., Kyushu Univ., 22, 153 - 160 (1978), Kaoru Okuyama, Masahiro Okamoto, Yoichi Aso, Katsuya Hayashi. 7. "Dynamic Characteristics of Enzymatic Feedback Systems", J. Fac. Agr., Kyushu Univ., 22, 179 - 194 (1978), Masahiro Okamoto, Yoichi Aso, Katsuya Hayashi. 8. "Enzymatic System Realizing Two-factor Model", J. Fac. Agr., Kyushu Univ., 22, 195 - 202 (1978), Michiko Tsukiji, Masahiro Okamoto, Satoru Kuhara, Yoichi Aso, Katsuya Hayashi. 9. "Dynamic Behavior of Enzymatic System Realizing Two-factor Model", J. Theor. Biol., 83, 1 - 16 (1980), Masahiro Okamoto, Atsuko Katsurayama, Michiko Tsukiji, Yoichi Aso, Katsuya Hayashi. 10. "Steady-state Approximation of Enzyme Activation and Inhibition", Biotechnol. and Bioengineer., 25, 1453 - 1463 (1983), Masahiro Okamoto, Youko Takeda, Yoichi Aso, Katsuya Hayashi. 11. "Dynamic Behavior of Cyclic Enzyme Systems", J. Theor. Biol., 104, 591 - 598 (1983), Masahiro Okamoto, Katsuya Hayashi. 12. "Optimal Control Mode of a Biochemical Feedback System", Bio Systems, 16, 315 - 321 (1984), Masahiro Okamoto, Katsuya Hayashi. 13. "Integrated Function of a Kinetic Proofreading Mechanism: Steady-State Analysis Testing Internal Consistency of Data Obtained In Vivo and In 　　 Vitro and Predicting Parameter Values", Biochemistry, 23, 1701 - 1709 (1984), Masahiro Okamoto, Michael A. Savageau. 14. "Integrated Function of a Kinetic Proofreading Mechanism: Dynamic Analysis Separating the Effects of Speed and Substrate Competition on Accuracy", Biochemistry, 23, 1710 - 1715 (1984), Masahiro Okamoto, Michael A. Savageau. 15. "Frequency Conversion Mechanism in Enzymatic Feedback Systems", J. Theor. Biol., 108, 529 - 537 (1984), Masahiro Okamoto, Katsuya Hayashi. 16. "Homeostatic Capability of Rate Sensitive Feedback System: Mathematical Model", Amer. J. Physiol., 247, R927 - R931 (1984), Masahiro Okamoto, Katsuya Hayashi. 17. "Kinetic Characteristics of Biochemical Cycle Reaction Systems: Amplification of Substrate Cycle System", Biotechnol. and Bioengineer., 27, 122 - 136 (1985), Masahiro Okamoto, Katsuya Hayashi. 18. "Control Mechanism for a Bacterial Sugar-Transport System: Theoretical Hypothesis", J. Theor. Biol., 113, 785 - 790 (1985), Masahiro Okamoto, Katsuya Hayashi. 19. "Homeostatic Capability of Enzymatic Feedback Systems I: Simple Feedback Inhibition in Unbranched Pathways", J. Inferent. Deduct. Biol., 1, 31 - 47 (1985), Masahiro Okamoto, Katsuya Hayashi. 20. "Homeostatic Capability of Enzymatic Feedback Systems II: Feedback Inhibition in Branched Pathways", J. Inferent. Deduct. Biol., 1, 49 - 60 (1985), Masahiro Okamoto, Katsuya Hayashi. 21. "酵素共役反応系の動的挙動 - 酵素スイッチ回路としての役割 - ", 生物物理, 26(1), 1 - 10 (1986), 岡本正宏, 林勝哉 . 22. "Integrated Function of a Kinetic Proofreading Mechanism: Double-Stage Proofreading by Isoleucyl-tRNA Synthetase", Biochemistry, 25, 1969 - 1975 (1986), Masahiro Okamoto, Michael A. Savageau. 23. "代謝制御系のコンピュータシミュレーション", 醗酵工学会誌, 64(2), 142 - 143 (1986), 岡本正宏 . 24. "生体反応解析とコンピュータ：解析例", 化学と生物, 25(1), 53 - 55 (1987), 岡本正宏 . 25. "Switching Mechanism of Cyclic Enzyme System: Role As a Chemical Diode", Bio Systems, 21, 1 - 11 (1987), Masahiro Okamoto, Toshio Sakai, Katsuya Hayashi. 26. "Biochemical Switching Device Realizing McCulloch-Pitts Type Equation", Biol. Cybern., 58, 295 - 299 (1988), Masahiro Okamoto, Toshio Sakai, Katsuya Hayashi. 27. "酵素スイッチ回路 - バイオミメティックケミストリーの立場から - ", システムと制御, 32(4), 227 - 234 (1988), 岡本正宏, 坂井俊夫, 林勝哉 . 28. "Biochemical Switching Device: Mono Cyclic Enzyme System", Biotechnol. and Bioengineer., 32, 527 - 537 (1988), Masahiro Okamoto, Toshio Sakai, Katsuya Hayashi. 29. "Biochemical Switching Device: How to Turn on (off) the Switch", Bio Systems, 22, 155 - 162 (1989), Masahiro Okamoto, Toshio Sakai, Katsuya Hayashi. 30. "生化学反応系のもつスイッチング機能", 機能材料, 9(11), 32 - 41 (1989), 岡本正宏. 31. "Network Study of Integrated Biochemical Switching System I: Connection of Basic Elements", Bio Systems, 24, 39 - 52 (1990), Masahiro Okamoto, Katsuya Hayashi. 32. "Development of Biochemical Switching Devices: Mathematical Model", Biomed. Biochim. Acta, 49, 917 - 933 (1990), Masahiro Okamoto. 33. "Biochemical Threshold-Logic Device Capable of Storing Short Memory: Mathematical Model and Network Study", Proc. of the 3rd. International Symposium on Bioelectronic and Molecular Electronic Devices, 1, 71 ? 72 (1990), Masahiro Okamoto. 34. "Development of Biochemical Threshold-Logic Device Capable of Storing 　　 Short-Memory", 　　 Annual International Conference IEEE/Engineering in Medicine and Biology Society, 12(4), 1770 - 1771 (1990), Masahiro Okamoto. 35. "生化学反応系を応用したオン・オフシステムの開発", 日産科学振興財団研究報告書, 14, 281 - 285 (1991), 岡本正宏. 36. "A Distributed Autonomous Control for Error-Proofreading in Biosynthetic System of Protein", 13th. Proceedings of World Congress on Computation and Applied Mathematics, 2, 1439 - 1441 (1991), Masahiro Okamoto. 37. "GTP-Dependent Kinetic Proofreading: An S-system Model of the Reaction of Poly(U)-Programmed Ribosomes with a Leucyl-tRNA・Elongation Factor Tu・GTP Complex", In: "Canonical Nonlinear Modeling: S-System Approach to Understanding Complexity" (ed. E.O.Voit), Van Nostrand Reinhold, New York, 166 -180, (1991), Masahiro Okamoto, Jun-ji Yoshii, Katsuya Hayashi. 38. "A Distributed Autonomous Control for Error-Proofreading in Biosynthetic System of Protein: Mathematical Model of GTP-dependent Kinetic Proofreading", In: "Biomedical Modeling and Simulation" (ed. J. Eisenfeld, D.S. Levine, M. Witten), Elsevier, North-Holland, 265 - 272, (1992), Masahiro Okamoto. 39. "複雑さ", 化学工学, 62(9), 513-514 (1998), 岡本正宏. 40. "Kinetics Behavior of G1-to-S Cycle Phase Transition Model", Genome Informatics, 14, 607 - 608 (2003), Yoshihiko Tashima, Taizo Hanai, Hirokuki Hamada, Masahiro Okamoto. 41. "細胞周期の数理モデル化と網羅的システム解析", ソフトウエアバイオロジー, 5, 11-14 (2006), 田島慶彦, 濱田浩幸, 岡本正宏, 花井泰三. 42. "Mathematical Modeling of G2/M Phase in Cell Cycle with Involving the p53/Mdm2 Oscillation System", Med. Biol. Comut. Proc. of IFMBE, 14, 195-198 (2006), Yoshihiko Tashima, Yu Kisaka, Taizo Hanai, Hiruyuki Hamada, Yukihiro Eguchi, Masahiro Okamoto. 43. "Mathematical Modeling and Sensitivity Analysis of G1/S Phase in the Cell Cycle Including the DNA Damage Signal Transduction Pathway", Proc. of Seventh International Workshop on Information Processing in Cells and Tissues (IPCAT2007) 281 - 292 (2007), Kazunari Iwamoto, Yoshihiko Tashima, Hiroyuki Hamada, Yukihiro Eguchi, Masahiro Okamoto. 44. "Prediction of Key Factor for Control of G1/S Phase in Mammalian Cell Cycle by using System Analysis", J. Bioscience and Boengineering, 106(4), 368-374 (2008), Yoshihiko Tashima, Hiroyuki Hamada, Masahiro Okamoto, Taizo Hanai. 45. "Mathematical Modeling and Sensitivity Analysis of G1/S Phase in the Cell Cycle Including the DNA Damage Signal Transduction Pathway", BioSystems, 94(1), 109-117 (2008), Kazunari Iwamoto, Yoshihiko Tashima, Hiroyuki Hamada, Yukihiro Eguchi, Masahiro Okamoto. 46. "Blind Spot of G1/S Checkpoint: G1/S Checkpoint is Invaded by DNA-Damage After R-Point", Proc. of the IASTED Intl. Symp. on Computational Biology and Bioinformatics (CBB2008), 241-246 (2008), Kazunari Iwamoto, Hiroyuki Hamada, Yukihiro Eguchi, Masahiro Okamoto. 47. "Sophisticated Framework Between Cell Cycle Arrest and Apoptosis Induction Based on p53 Dynamics", Molecular Systems Biology (submitted), Hiroyuki Hamada, Yoshihiko Tashima, Yu Kuriya, Kazunari Iwamoto, Taizo Hanai, Yukihiro Eguchi, Masahiro Okamoto. 　Ｂ．代謝制御反応系における解析用統合シミュレータの設計・開発研究 1. "Development of Biosimulator for Analyzing Nonlinear Reaction Network", Proc. of the 5th. Intl. Symp. of Process System Engng., Vol. 1, 641-647 (1994), Yoshimitsu Morita, Masahiro Okamoto. 2. "BEST-KIT; Development of Biochemical Engineering System Analyzing Tool-KIT (Kyushu Institute of Technology)", Proc. of 6-th. Intl. Conf. on Computer Applications in Biotechnology 383-386 (1995), Masahiro Okamoto, Yoshimitsu Morita. 3. "Toward a Virtual-Labo-System for Metabolic Engineering: Development of Biochemical Engineering System Analyzing Tool-KIT (BEST-KIT)", Proceeding of Pacific Symposium on Biocomputing '97 (ed. by R.B. Altman, A.K. Dunker, L. Hunter, T.E. Klein, World Scientific, New Jersey, 304-315 (1997), Masahiro Okamoto, Yoshimitsu Morita, Daisuke Tominaga, Kouji Tanaka, Noriaki Kinoshita, Jun-Ichi Ueno, Yuichi Miura, Yukihiro Maki, Yukihiro Eguchi. 4. "Design of Virtual-Labo-System for Metabolic Engineering: Development of Biochemical Engineering System Analyzing Tool-KIT (BEST-KIT)", Computers Chem. Engng., 21, S745-S750 (1997), Masahiro Okamoto, Yoshimitsu Morita, Daisuke Tominaga, Kouji Tanaka, Noriaki Kinoshita, Jun-Ichi Ueno, Yuichi Miura, Yukihiro Maki, Yukihiro Eguchi. 5. "Towards a Virtual-Lab-System for Metabolic Engineering: Development of Biochemical Engineering System Analyzing Tool-KIT (BEST-KIT)", Dagstuhl-Seminar-Report, 215 (Modeling and Simulation of Gene and Cell Regulation and Metabolic Pathways), 47-49 (1998), Masahiro Okamoto. 6. "BEST-KIT: Development of Biochemical Engineering System Analyzing Tool-KIT", The first Intl. Conf. on System Biology, 124-129 (2000), Kenji Sakuraba, Jun-ichi Ueno, Masakazu Mori, Kouji Tanaka, Jun Yoshimura, Masahiro Okamoto. 7. "Web-based BEST-KIT: Development of Web-based Biochemical Engineering System Analyzing Tool-KIT", Chem-Bio Informatics J. 2(1), 1-17 (2002), Masahiro Okamoto, Kenji Sakuraba, Jun Yoshimura, Kouji Tanaka, Jun-ichi Ueno, Masakazu Mori, Tadahiro Simonobou, Tatsuya Sekiguchi. 8. "細胞内ネットワークのシステム論的解析の現状と未来：遺伝子 ネットワーク推定と代謝経路解析を例として", ソフトウエアバイオロジー, 1, 45-51 (2002), 岡本正宏. 9. "BEST-KIT: Development of Biochemical Engineering System Analyzing Tool-KIT", Proceeding of Process System Engineering Asia 2002, 357-362 (2002), Tadahiro Shimonobou, Jun Yoshimura, Tatsuya Sekiguchi, Masahiro Okamoto. 10. "Development of the Parameter-fitting Module for Web-based Biochemical Reaction Simulator BEST-KIT", Chem-Bio Informatics J., 3(3), 114-129 (2003), Jun Yoshimura, Tadahiro Shimonobou, Tatsuya Sekiguchi, Masahiro Okamoto. 11. "WinBEST-KIT (Biochemical Reaction Simulator for Analyzing Metabolic Pathways): Application to the System Analysis of Acetone-Butanol- Ethanol Fermentation in Clostridium saccharoperbutylacetonicum", Proceedings of Asia-Pacific Biochemical Engineering Conference 2005, SYS1-07 (CD-ROM, 原稿枚数4枚) (2005), Tatsuya Sekiguchi, Hideaki Shinto, Yukihiro Tashiro, Genta Kobayashi, Taizo Hanai, Kenji Sonomoto, Masahiro Okamoto. 12. "Kinetic Modeling of Metabolic Pathways in Acetone-Butanol-Ethanol (ABE) Fermentation Using Novel Simulator", Genome Informatics, 16, P120_1-P120_2 (2005), Hideaki Shinto, Yukihiro Tashiro, Mayu Yamashita, Genta Kobayashi, Tatsuya Sekiguchi, Taizo Hanai, Masahiro Okamoto, Kenji Sonomoto. 13. "System Analysis Using WinBEST-KIT", ソフトウエアバイオロジー, 5, 48-60 (2006), Tatsuya Sekiguchi, Masahiro Okamoto. 14. "WinBEST-KIT: Windows-based Biochemical Reaction Simulator for Metabolic Pathways" Journal of Bioinformatics and Computational Biology, 4(3), 621-638 (2006), Tatsuya Sekiguchi, Masahiro Okamoto. 15. "Kinetic Modeling and Sensitivity Analysis of Acetone-Butanol-Ethanol Production", Journal of Biotechnology, 131(1), 45-56 (2007), Hideaki Shinto, Yukihiro Tashiro, Mayu Yamashita, Genta Kobayashi, Tatsuya Sekiguchi, Taizo Hanai, Yuki Kuriya, Masahiro Okamoto, Kenji Sonomoto. 16. "Kinetic Study of Substrate Dependency for Higher Butanol Production in Acetone-Butanol-Ethanol Fermentation", Process Biochemistry, 43(12), 1452-1461 (2008) Hideaki Shinto, Yukihiro Tashiro, Genta Kobayashi,Tatsuya Sekiguchi, Taizo Hanai, Yuki Kuriya, Masahiro Okamoto, Kenji Sonomoto. 17. "Kinetic Modelling and Sensitivity Analysis of Xylose Metabolism in Lactoccocus lactis lO-1", Journal of Bioscience and Bioengineering (submitted), Mugihito Ohshiro, Hideaki Shinto, Yukihiro Tashiro, Niroko Miwa, Tatsuya Sekiguchi, Masahiro Okamoto, Tenji Sonomoto. 　Ｃ．大規模遺伝子ネットワークの相互作用推定システムの設計・開発研究 1. "Nonlinear Numerical Optimization with Use of a Hybrid Genetic Algorithm Incorporated the Modified Powell Method", Proc. of Intl. Sympo. on Artificial Life and Robotics, 89-92, (1996), Masahiro Okamoto, Taisuke Nonaka, Shuichiro Ochiai, Daisuke Tominaga. 2. "Discovery of a Skeletal Network Describing Complex Nonlinear Dynamics: Optimized Essential Model for Temporal Input-Output Matching", In: "4th Intl. Conf. on Soft Computing", Fuzzy Logic Systems Institute, Vol. 2, 65 - 80, (1996), Daisuke Tominaga, Jun-Ichi Ueno, Yuichi Miura, Masahiro Okamoto. 3. "Nonlinear Numerical Optimization with Use of a Hybrid Genetic Algorithm Incorporated the Modified Powell Method", Applied Mathematics and Computation, 91, 63-72 (1998), Masahiro Okamoto, Taisuke Nonaka, Shuichiro Ochiai, Daisuke Tominaga. 4. "Design of Canonical Model Describing Complex Nonlinear Dynamics", Proceeding of 7th Intl. Conf. on Computer Applications in Biotechnology, 85-90 (1998), Daisuke Tominaga, Masahiro Okamoto. 5. "Algorithms for Inference of Genetic Networks (AIGNET)", Genome Informatics, 9, 274-275 (1998), Shoji Watanabe, Yukihiro Maki, Yukihiro Eguchi, Daisuke Tominaga, Masahiro Okamoto. 6. "逆問題(inverse problem)解決のための遺伝的アルゴリズムを用いた 　　 多次元非線形数値最適化手法の開発", 化学工学論文集, 25(2), 220-225 (1999), 富永大介, 岡本正宏. 7. "Nonlinear Numerical Optimization Technique Based on a Genetic Algorithm for Inverse Problems: Towards the Inference of Genetic Networks", Proceeding of German Conference on Bioinformatics '99, 127-140, (1999), Daisuke Tominaga, Masahiro Okamoto, Yukihiro Maki, Shoji Watanabe, Yukihiro Eguchi. 8. "Inference Algorithm for Interaction Mechanism in Genetic Network Using Experimentally Observed Time-course Data", Proc. of the 2nd Intl. Workshop on Advanced Genomics, 1, 76-76 (1999), Daisuke Tominaga, Masahiro Okamoto, Yukihiro Maki, Shoji Watanabe, Yukihiro Eguchi. 9. "AIGNET: A System That Inferes Large Scale Genetic Networks", Genome Informatics, 10, 253-254 (1999), Yukihiro Maki, Shoji Watanabe, Yukihiro Eguchi, Daisuke Tominaga, Masahiro Okamoto. 10. "Towards a System for the Inference of Large Scale Genetic Networks: Efficient Numerical Optimization Algorithm Based on Genetic Algorithm for Inverse Problem", IPSJ Symposium Series, 2000(5), 29-37 (2000), Masahiro Okamoto, Daisuke Tominaga, Nobuto Koga, Yukihiro Maki, Shoji Watanabe, Yukihiro Eguchi. 11. "Efficient Numerical Optimization Algorithm Based on Genetic Algorithm for Inverse Problem", Proc. of Genetic and Evolutionary Computation Conference (GECCO 2000) 252 - 258 (2000), Daisuke Tominaga, Nobuto Koga, Masahiro Okamoto. 12. "AIGNET: Improvement of a System and Application to the Experimentally Observed Expression Data", Genome Informatics, 11, 291-292 (2000), Yuji Arikawa, Shoji Watanabe, Yukihiro Eguchi, Yukihiro Maki, Daisuke Tominaga, Masahiro Okamoto. 13. "Efficient Numerical Optimization Algorithm Based on Genetic Algorithm for Inverse Problem: System for the Inrefence of Genetic Networks", Proc. of 1st. Intl. Conf. on Systems Biology (ICSB2000), 130 - 135 (2000), Masahiro Okamoto, Daisuke Tominaga, Nobuto Koga, Yukihiro Maki. 14. "Development of a System for the Inference of Large Scale Genetic Networks", Pacific Symposium on Biocomputing 2001 (PSB2001) 446-458 (2001), Yukihiro Maki, Daisuke Tominaga, Masahiro Okamoto, Shoji Watanabe, Yukihiro Eguchi. 15. "Inference of a Genetic Network Using Experimental Time Series Data by Using AIGNET", Genome Informatics, 12, 274-275 (2001), Yuji Arikawa, Yoriko Takahashi, Shoji Watanabe, Yukihiro Maki, Masahiro Okamoto, Yukihiro Eguchi. 16. "Efiicient Numerical Optimization Technique Based on Real-coded Genetic Algorithm", Genome Informatics, 12, 451-453 (2001), Takanori Ueda, Nobuto Koga, Masahiro Okamoto. 17. "Efiicient Numerical Optimization Technique Based on Real-coded Genetic Algorithm for Inverse Problem", Proc. of 7th. Int. Symp. on Artificial Life and Robotics (AROB 7th '02), 1, 290-293 (2002), Takanori Ueda, Nobuto Koga, Isao Ono, Masahiro Okamoto. 18. "Efficient Numerical Optimization Algorithm Based on Genetic Algorithm for Inverse Problem: Towards a System for the Inference of Large Scale Genetic Networks", Math. Biosci. (submitted), Daisuke Tominaga, Nobuto Koga, Masahiro Okamoto. 19. "Application of Numerical Optimization Technique Based on Real- coded Genetic Algorithm to Inverse Problem in Biochemical Systems", Proc. of Genetic and Evolutionary Computation Conference (GECCO 2002), 701 (2002), Takanori Ueda, Nobuto Koga, Isao Ono, Masahiro Okamoto. 20. "Inference of Genetic Network Using the Expression Profile Time Course Data of Mouse P19 Cells", Genome Informatics, 13, 382-383 (2002), Yukihiro Maki, Takanori Ueda, Masahiro Okamoto, Naoya Uematsu, Kentaro Inamura, Kazuhiko Uchida, Yoriko Takahashi, Yukihiro Eguchi. 21. "Development of System Identification Technique Based on Real-Coded Genetic Algorithm", Genome Informatics, 13, 386-387 (2002), Takanori Ueda, Isao Ono, Masahiro Okamoto. 22. "実数値GAに基づく効率的な数値最適化手法の開発：逆問題における 多変数最適化への応用", MPSシンポジウム, 127-134 (2003), 上田尚学, 小野 功, 岡本正宏. 23. "実数値GAのバイオ分野への応用；大規模遺伝子ネットワークの 相互作用推定", 人工知能学会誌, 18(5), 502-509 (2003), 岡本正宏, 小野 功. 24. "A Grid-Oriented Genetic Algorithm for Estimating Genetic Networks by S-Systems", Proc. SICE Annual Conf. 2003 in Fukui, 3317- 3322 (2003), Hiroaki Imade, Ryohei Morishita, Isao Ono, Masahiro Okamoto. 25. "Finding Multiple Solutions Based on an Evolutionary Algorithm for Inference of Genetic Networks by S-system", Proc. 2003 Congress on Evolutionary Computation (CEC2003), 615-622 (2003), Ryohei Morishita, Hiroaki Imade, Isao Ono, Norihiko Ono, Masahiro Okamoto. 26. "A Framework of Grid-Oriented Genetic Algorithms for Large-Scale Optimization in Bioinformatics", Proc. 2003 Congress on Evolutionary Computation (CEC2003), 623-630 (2003), Hiroaki Imade, Ryohei Morishita, Isao Ono, Norihiko Ono, Masahiro Okamoto. 27. "遺伝子ネットワーク推定における複数代替案発見のための遺伝的アルゴリズム の提案", システム・情報部門学術講演会2003講演論文集, 155-160 (2003), 森下領平, 今出広明, 小野功, 小野典彦, 岡本正宏. 28. "Integrated System for Inference of Gene Expresion Network", Genome Informatics, 14, 282-283 (2003), Masahiko Nakatsui, Takanori Ueda, Masahiro Okamoto. 29. "Clustering Method Based on Onset and Cessation of Gene Expression", Genome Informatics, 14, 330-331 (2003), Kazumi Hakamada, Taizo Hanai, Masahiro Okamoto. 30. "Gene Expression Analysis Using Fuzzy K-Means Clustering", Genome Informatics, 14, 334-335 (2003), Chinatsu Arima, Taizo Hanai, Masahiro Okamoto. 31. "Prognosis Prediction by Microarray Gene Expression Using Support Vector Machine", Genome Informatics, 14, 324-325 (2003), Chihoko Tago, Taizo Hanai, Masahiro Okamoto. 32. "Analysis of Genetic Networks Using Time-course Data of Gene Expression Profiling", Cytometry Research, 13(2), 45-53 (2003), Naoya Uematsu, Yukihiro Maki, Masahiro Okamoto, Kazuhiko Uchida. 33. "物質間の相互作用を考慮した遺伝子ネットワーク推定のための進化 アルゴリズムの提案", 第31回知能シンポジウム, 109-114 (2004), 清家嘉昭, 森下領平, 小野功, 小野典彦, 中津井雅彦, 岡本正宏. 34. "A Grid-Oriented Genetic Algorithm Framework for Bioinformatics", New Generation Computing, 22, 177-186 (2004), Hiroaki Imade, Ryohei Morishita, Isao Ono, Norihiko Ono, Masahiro Okamoto. 35. "An Evolutionary Algorithm Taking Account of Mutual Interactions Among Substances for Inference of Genetic Networks", Proc. of 2004 Congress on Evolutionary Computation (CEC2004), 2060-2067 (2004), Isao Ono, Yoshiaki Seike, Ryohei Morishita, Norihiko Ono, Masahiko Nakatsui, Masahiro Okamoto. 36. "Integrated Comprehensive Workbench for Inferring Genetic Network: VOYAGENE", J. Bioinformatics and Computational Biology, 2(3), 533-550 (2004), Yukihiro Maki, Yoriko Takahashi, Yuji Arikawa, Shoji Watanabe, Ken Aoshima, Yukihiro Eguchi, Takanori Ueda, Sachiyo Aburatani, Satoru Kuhara, Masahiro Okamoto. 37. "Gridifying: An EvolutionaryAlgorithm for Inference of Genetic Networks Using the Improved GOGA Framework and its Performance Evaluation on OBI Grid", Grid Computing in Life Science (Lecture Notes in Bioinformatics, 3370), 171-186 (2005), Hiroaki Imade, Naoaki Mizuguchi, Isao Ono, Norihiko Ono, Masahiro Okamoto. 38. "Fuzzy k-means clusteringを用いたDNAマイクロアレイデータ解析および 　　　クラスター数の推定", ソフトウエアバイオロジー, 5, 7-10 (2006), 有馬千夏, 袴田和巳, 岡本正宏, 花井泰三. 39. "Novel Technique for Preprocessing High Dimensional Tome-course Data from DNA Microarray: Mathematical Model-Based Clustering", Bioinformatics, 22(7), 843-848 (2006), Kazumi Hakamada, Masahiro Okamoto, Taizo Hanai. 40. "Application of Bioinformatics for DNA Microarray Data to Bioscience, Bioengineering and Medical Field", J. Biosci. Bioeng., 101(5), 377-384 (2006), Taizo Hanai, Hiroyuki Hamada, Masahiro Okamoto. 41. "Multi-layered Network Structure of Amino Acid (AA) Metabolism Characterized by Each Essential AA-deficient Condition”, Amino Acids, 33(1), 113-121 (2007), Nahoko Shikata, Yukihiro Maki, Yasushi Noguchi, Masato Mori, Taizo Hanai, Michio Takahashi, Masahiro Okamoto. 42. "Integrated Comprehensive Workbench for Systems Biology: Inference of Genetic Interaction and Systems Analysis of Metabolic Pathways", Proc. of 11th. World Multi Conference on Systemics, Cybernetics and Informatics (WMSCI2007), 7-12 (2007), Masahiko Nakatsui, Yukihiro Maki, Tatsuya Sekiguchi, Masahiro Okamoto. 43. "Modified Fuzzy Gap Statistic for Estimating Preferable Number of Clusters in Fuzzy k-Means Clustering", Journal of Bioscience and Bioengineering, 105, 273-281(2008), Chinatsu Arima, Kazumi Hakamada, Masahiro Okamoto, Taizo Hanai. 44. "Efficient Inferring Method of Genetic Interactions based on Time-Series of Gene Expression Profile", Proc. of 13th. International Symposium on Artificial Life and Robotics (AROB 13th ’08), 71-76 (2008), Masahiko Nakatsui, Takanori Ueda, Yukihiro Maki, Isao Ono, Masahiro Okamoto. 45. "Method for Inferring and Extracting Reliable Genetic Interactions from Time-series Profile of Gene Expression", Mathematical Biosciences, 215, 105-114 (2008), Masahiko Nakatsui, Takanori Ueda, Yukihiro Maki, Isao Ono, Masahiro Okamoto. 46. "An Algebraic-Numeric Algorithm for the Model Selection in Kinetic Network with Feedback Loop", Proc. of Algebraic Biology 2008, (in press), Masahiko Nakatsui, Hiroshi Yoshida, Masahiro Okamoto, Katsuhisa Horimoto. 47. "Determining Important Regulatory Relations of Amino Acids from Dynamic Network Analysis of Plasma Amino Acids", Amino Acids (in press), Nahoko Shikata, Yukihiro Maki, Masahiko Nakatsui, Yasushi Noguchi, Shintaro Yoshida, Michio Takahashi, Nobuo Kondo, Masahiro Okamoto. 　Ｄ．生物機能の工学的応用研究 1. "生化学反応系を利用したニューロチップの設計", 　　 信学技報, NC89-79, 107-112 (1990), 　　 岡本正宏. 2. "Biochemical Switching Device: Biomimetic Approach and Application to Neural Network Study", J. Biotechnol., 24, 109 - 127 (1992), Masahiro Okamoto. 3. "酵素スイッチ回路", 数理科学, 30(2), 26 -32 (1992) 岡本正宏, 牧幸浩. 4. "バイオケミカルニューロン", 計測自動制御学会誌, 31(11), 1197 (1992), 岡本正宏, 関口達也, 牧幸浩. 5. "Biochemical Neuron: Application to Neural Network Study and Practical Implementation of Device", In: "Modern Trends in Biothemokinetics" (ed. J-P. Mazat, S. Schuster, M. Rigoulet), Plenum, London, 167 - 172, (1993),　 Masahiro Okamoto, Yukihiro Maki, Tatsuya Sekiguchi. 6. "Information Processing of Neural Network System Composed of Biochemical Neuron", Proc. of the 3rd. Intl. Conf. on Fuzzy Logic, Neural Nets and Soft Computing, 571-574 (1994), Masahiro Okamoto, Satoshi Yoshida, Yoshimitsu Morita, Yukihiro Maki, Tatsuya Sekiguchi. 7. "酵素反応のシステム利用 - 酵素スイッチ - ", ケミカルエンジニアリング, 39(10), 34 - 39 (1994), 岡本正宏. 8. "Self-Organization in a Biochemical-Neuron Network", Physica D, 84, 194-203 (1995), Masahiro Okamoto, Yukihiro Maki, Tatsuya Sekiguchi, Satoshi Yoshida. 9. "ナチュラルインテリジェンスを模倣した新機能素子の設計・開発： 生体内代謝制御システムに学ぶ", システム制御情報学会論文誌, 8(8), 331-343 (1995), 岡本正宏, 関口達也, 牧幸浩, 田中康司. 10. "Information Processing of Neural Network System Composed of Biochemical Neuron: Recognition of Pattern Similarity in Time-variant External Analog Signals", Proc. of Intl. Workshop on Information Processing in Cells and Tissues, 318-328 (1995), Masahiro Okamoto, Kouji Tanaka, Yukihiro Maki, Satoshi Yoshida. 11. "３次元物体の形状変化を認識する学習ネットワークGRBF (Generalized Radial Basis Function)の構築", 信学技報, MBE94-112, 9 - 16 (1995), 宮崎哲哉, 岡本正宏. 12. "Information Processing and Practical Implementation of Biochemical Neuron", In: "World Congress of Nonlinear Analysts '92" (ed. V. Lakshmikantham), Walter de Gruyter, New York, 3235 - 3244 (1996), Masahiro Okamoto, Yukihiro Maki, Tatsuya Sekiguchi. 13. "Recognition of Pattern Similarity in Time Series Signals Using Artificial Neural Network with Synaptic History", In: "Methodologies for the Conception, Design, and Application of Intelligent Systems" (ed. T. Yamakawa, G. Matsumoto), World Scientific, New Jersey, 671 - 675 (1996), Kouji Tanaka, Masahiro Okamoto. 14. "Artificial Life Model Describing Developmental Processes of Plants: L-system Model Reflecting on Cell-Differentiation and Cell-Death", Proc. of 2nd Intl. Sympo. on Artificial Life and Robotics, 22-27 (1997), Yuka Arima, Masahiro Okamoto. 15. "Recognition of Shapes and Shape-Changes in 3D-Objects by GRBF (Generalized Radial Basis Function) Network: Structural Learning Algorithm to Explore the Small-Sized Network", In: "Methodologies for the Conception, Design, and Application of Intelligent Systems" (ed. T. Yamakawa, G. Matsumoto), World Scientific, New Jersey, 592 - 597 (1998), Masahiro Okamoto, Noriaki Kinoshita, Takanori Katsuki, Tetsuya Miyazaki, Miwako Hirakawa. 16. "Recognition System of Pattern Similarity in Time Series Signals Using Neural Network Being Composed of "Biochemical Neurons", In: "The 5th. Intl. Conf. on Neural Information Processing" (ed. S. Usui, T. Omori), Ohmusha, Tokyo, 1073-1077 (1998), Kouji Tanaka, Tatsuya Sekiguchi, Kumiko Kawamoto, Masahiro Okamoto. 17. "Recognition of Shapes and Shape-Changes in 3D Objects by GRBF (Generalized Radial Basis Function) Network", Proc. of 3rd Intl. Sympo. on Artificial Life and Robotics, 228-233 (1998), Noriaki Kinoshita, Takanori Katsuki, Tetsuya Miyazaki, Miwako Hirakawa, Masahiro Okamoto. 18. "ナチュラルインテリジェンスに学ぶ知的通信技術：生体内代謝経路 を用いた情報通信の恒常性探索と機能素子の探索", Telecom Frontier (SCAT Technical Journal), 21, 2-11 (1998), 岡本正宏. 19. "Design of Recognition System of Pattern Similarity in Time Series Signals Using Neural Network Composed of "Biochemical Neurons": Biomimetic Study", Proceeding of Intl. Symp. on Future of Intellectual Integrated Electronics, 459-468 (1999), Kouji Tanaka, Kumiko Kawamoto, Tatsuya Sekiguchi, Masahiro Okamoto. 20. "Biochemical Neuron: Hardware Implementation of Functional Devices by Mimicking the Natural Intelligence Such As Metabolic Control Systems", Computers and Electric. Engng., 25(5), 421-438 (1999), Masahiro Okamoto, Tatsuya Sekiguchi, Kouji Tanaka, Yukihiro Maki, Satoshi Yoshida. 21. "New Analytical Solution for Pyle-Popovich's Peritoneal Dialysis Model", J. of Chem. Engng. of Japan, 32(4), 498-505 (1999), Hiroyuki Hamada, Ryoichi Sakiyama, Akihiro C. Yamashita, Masahiro Okamoto, Kakuji J. Tojo. 22. "Recognition of the Sequential Motion of the Hand by the GRBF network", Proc. of 5th Intl. Sympo. on Artificial Life and Robotics, 534-538 (2000), Miwako Hirakawa, Masami Ishibashi, Taeko Murakami, Masahiro Okamoto. 23. "Validation of the New Analytical Solution for Pyle-Popovich's Model Using Rabbit in Vivo Experimental Data", Nephrology, 5, 59-64 (2000), Hiroyuki Hamada, Ryoichi Sakiyama, Akihiro C. Yamashita, Masahiro Okamoto, Kakuji J. Tojo, Kazuo Kumano, Tadasu Sakai. 24. "Recognition of Shapes and Shape Changes in 3D-objects by GRBF Network: A Structural Learning Algorithm to Explore Small-sized Networks", In: "Pattern Recogntion in Soft Computing Paradigm" (ed. N.R. Pal), World Scientific, New Jersey, 181-195 (2001), Masahiro Okamoto, Miwako Hirakawa, Noriaki Kinoshita, Takanori Katsuki, Tetsuya Miyazaki, Masami Ishibashi. 25. "Hebbian Learning in a Network of Biochemical Neurons", In: "Biophysical Neural Networks: Analytical Approaches to Neuronal Function" (ed. R.R. Poznanski), Mary Ann Libert, Inc. Publishers, New York, 123-146 (2001), Masahiro Okamoto, Kouji Tanaka. 26. "Biophysical Recognition System of Time-series Analog Signals Using Hebbian Learning Network", Chem-Bio Informatics J., 2(2), 38-57 (2002), Kouji Tanaka, Masahiro Okamoto. 27. "フォルトトレラントな生命型情報通信ネットワークトポロジーの構築に 向けて：酵素反応系のフィードバック制御をモデルにした適応型 ルーティングの設計・開発", Telecom Frontier (SCAT Technical Journal), 37, 2-9 (2002), 岡本正宏. 28. "酵素反応系のフィードバック制御をモデルにした適応型ルーティング の設計・開発", ソフトウエアバイオロジー, 2, 18-25 (2003), 平川幹和子, 岡本正宏. 29. "Recognition of the Sequential Motion (Hand Shape-Chenge) by the GRBF Network", Proc. European Conf. on Computational Biol. (ECCB'2003), 615-616 (2003), Miwako Hirakawa, Masahiro Okammoto. 30. "Biomimetic Design of Adaptive Routing Based on Fedback Control Mechanism of Enzymatic Reaction System in the Cell", Proc. Intl. Conf. on Computing, Communications and Control Technologies (CCCT2004), 5, 386-390 (2004), Takashi Kawauchi, Masahiro Okamoto, Miwako Hirakawa. 31. "Development of a computer-aided diagnosis system for a new modality of renal replacement therapy: An integrated approach combining both peritoneal dialysis and hemodialysis", Computers in Biology and Medicine, 35, 845-861 (2005), Hiroyuki Hamada, Shinji Namoto, Ryo Yamada, Makoto Ishizaki, Masahiro Okamoto. 32. "Evidence for a Novel Racemization Process of Asparaginyl Residue in Mouse Lysozyme under Physiological Conditions", Cellular and Molecular Life Sciences, 62, 199-205 (2005), Keisuke Ueno, Tadashi Ueda, Kei Sakai, Yoshito Abe, Naotaka Hamasaki, Masahiro Okamoto, Taiji Imoto. 33. "Design of Novel Adaptive Routing by Mimicking Enzymic Feedback Control Mechanism in the Cell", Proc. 10th. Artificial Life and Robotics (AROB 10th'05), GS14-3 (2005), Takashi, Kawauchi, Masahiro Okamoto, Miwako Hirakawa. 34. "Biologically Inspired Adaptive Routing by Mimicking Enzymic Feedback Control Mechanism in the Cell", Lecture Notes in Computer Science, 3853, 371-378 (2006), Takashi Kawauchi, Tadasuke Nozoe, Masahiro Okamoto. 35. "腹膜透析療法プラニングソフトウエアの開発", ソフトウエアバイオロジー, 5, 3-6 (2006), 濱田浩幸, アブデュラーマムン, 花井泰三, 岡本正宏. 36. "Availability of a Novel Criterion for Pertioneal Diffusive Selectivity on Peritoneal Dialysis", Med. Biol. Eng. Comput. Proc. of IFMBE, 14, 3074 - 3077 (2006), Hiroyuki Hamada, Abdula A, Mamun, Tomokazu Karino, Shinji Namoto, Akihiro C. Yamashita, Makoto Ishizaki, Masahiro Okamoto. 37. "A Bio-inspired Adaptive Routing Based on Enzymatic Feedback Control Mechanism in Metabolic Networks", Proc. of International MultiConference of Engineers and Computer Scientists 2007 (IMECS2007), 1361-1365 (2007), Tadasuke Nozoe, Takashi Kawauchi, Masahiro Okamoto. 38. "Design of Bio-inspired Fault-tolerant Adaptive Routing Based on Enzymatic Feedback Control in the Cell: Towads Averaging Load Balance in the Network", Proc. of Frontiers in the Convergence of Bioscience and Information Technologies (FBIT2007), 854-860 (2007), Akiyuki Iwasaki, Tadasuke Nozoe, Takashi Kawauchi, Masahiro Okamoto. 39. "Development of a Computer-aided Diagnosis System for Continuous Peritoneal Dialysis: An Availavilty of the Simultaneous Numerical Optimizaton Technique for Kinetic Parameters in the Peritoneal Dialysis Model", Computers in Biology and Medicine, 37, 12, 1700-1708 (2007), Hiroyuki Hamada, Shinji Namoto, Ryo Yamada, Abdula A. Mamun, Akihiro C. Yamashita, Makoto Ishizaki, Masahiro Okamoto. 40. "Clinical Application of Computer-Aided Diagnostic System for Harmonious Introduction of Complementary Dialysis Theraphy", The Open Biomedical Rngineering J., 2, 10-16 (2008), Abdullah Al. Mamun, Hiroyuki Hamada, Tomokazu Karino, Shinji Namoto, Akihiro C. Yamashita, Makoto Ishizaki, Masahiro Okamoto. 41. "Fault Tolerant Mechanism of Bio-inspired Adaptive Routing System", Proc. of 3rd Intl. Conf. on Bio-Inspired Models of Network, Information, and Computing Systems (BIONETICS 2008), CD-ROM 6 pages, (2008), Akiyuki Iwasaki, Tadasuke Nozoe, Takashi Kawauchi, Masahiro Okamoto, U. 著書・総説 1. "実験器具としてのパーソナルコンピュータ", 生物物理, 21(1), 57 - 60 (1981), 麻生陽一, 久原哲, 岡本正宏. 2. "酵素反応系の動的挙動(I): 単一酵素反応系および巨視的取り扱い", In: "酵素反応のダイナミクス", 林勝哉, 坂本直人　編著, 学会出版センター (1981), pp. 53 - 128, 岡本正宏. 3. "酵素反応制御系の動的解析", In: "バイオテクノロジーとコンピュータ利用", 神沼二真　編著, シーエムシー (1985), pp. 154 - 164, 岡本正宏. 4. "Analysis of Enzymatic Reactions in Closed System" In: "Dynamic Analysis of Enzyme Systems: Introduction", (eds. Katsuya Hayashi and Naoto Sakamoto), Springer-Verlag, New York, (1986), pp. 89 - 162, Masahiro Okamoto, Katsuya Hayashi. 5. "Macroscopic Analysis of Enzyme Systems" In: "Dynamic Analysis of Enzyme Systems: Introduction", (eds. 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