本文へスキップ

研究業績ACHIEVEMENTS

2000年以降の主な英文原著論文、総説、単行本、研究報告等


1. Imai, H., Moriyasu, K., Nakahata, A., Maebuchi, M., Ichinose, T., Furuya, S. (2017) Soy peptide ingestion ingestion augments the synthesis and metabolism of noradrenaline in the mouse brain. Biosci. Biotech. Biochem. 81, 1007-1013
2. Fukano, Y., Okino, N., Furuya, S., Ito, M. (2016) A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration. Biochemical and Biophysical Research Communications, 478, 624-630.
3. Hamano, M., Sayano, T., Kusada, W, Kato, H., Furuya, S. (2016) Microarray data on altered transcriptional program of Phgdh-deficient mouse embryonic fibroblasts caused by L-serine depletion. Data in Brief. 7, 1598–1601 (doi:10.1016/j.dib.2016.04.052)
4. Sayano, T., Kawano, Y., Kusada, W., Arimoto, Y., Esaki, K., Hamano, M., Udono, M., Katakura, Y., Ogawa, Y., Kato, H., Hirabayashi, Y., Furuya, S. (2016) Adaptive response to L-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts. FEBS Open Bio. doi: 10.1002/2211-5463.12038
5. Moriyasu, K., Ichinose, T., Nakahata, A., Tanaka, M., Matsui, T., Furuya, S. (2016) The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem. Int. J. Pept. vol. 2016, Article ID 6020786, 5 pages. doi:10.1155/2016/6020786
6. Esaki, K., Sayano, T., Sonoda, C., Akagi, T., Suzuki, T., Ogawa, T., Okamoto, M., Yoshikawa, T., Hirabayashi, Y., Furuya, S. (2015) L-Serine deficiency elicits intracellular accumulation of cytotoxic deoxy-sphingolipids and lipid body formation. J. Biol. Chem. 290, 14595-14609.
7. Ichinose, T., Moriyasu, K., Nakahata, A., Tanaka, M., Matsui, T., Furuya, S. (2015) Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain. Biosci. Biotech. Biochem. 79, 1542-1547.
8. 古屋 茂樹,佐矢野 智子,江﨑 加代子 (2014) 個体発生と高次機能制御におけるde novoセリン合成の必須性. 特集「アミノ酸機能のニューパラダイム」,生化学, 14, 372-381.
9. Ehmsen, J.T., Ma, T.M., Sason, H., Rosenberg, D., Ogo, T., Furuya, S., Snyder, S.H., Wolosker, H. (2013) D-Serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase. J. Neurosci. 33, 12464-12469.
10. Sayano, T., Kawakami, Y., Kusada, W., Suzuki, T., Kawano, Y., Watanabe, M., Takashima, K., Arimoto, Y., Esaki, K., Wada, A., Yoshizawa, F., Watanabe, M., Okamoto, M., Hirabayashi, Y., Furuya, S. (2013) Serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the central nervous system. FEBS J. 280, 1502-1517.
11. Takao, K., Kobayashi, K., Hagihara, H., Ohira, K., Shoji, H., Hattori, S., Koshimizu, H., Umemori, J., Toyama, K., Nakamura, H.K., Kuroiwa, M., Maeda, J., Atsuzawa, K., Esaki, K., Yamaguchi, S., Furuya, S., Takagi, T., Walton, N.M., Hayashi, N., Suzuki, H., Higuchi, M., Usuda, N., Suhara, T., Nishi, A., Matsumoto, M., Ishii, S., Miyakawa, T. (2013) Deficiency of Schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38, 1409-1425.
12. Esaki, K., Ohmori, T., Maebuchi, M., Nakamori, T., Ohshima, T., Furuya, S. (2013) Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY. Biosci. Biotech. Biochem. 77, 847-849.
13. Suzuki, M., Sasabe, J., Furuya, S., Hamase, K., Aiso, S. (2012) Type 1 diabetes mellitus in mice increases hippocampal D-serine in the acute phase after streptozotocin injection. Brain Res. 1466, 167-176.
14. 古屋 茂樹 (2012) 3-ホスホグリセリン酸脱水素酵素欠損症. 別冊 日本臨牀 新領域別症候群シリーズ No.19「先天代謝異常症候群(第2版)ー病因・病態研究,診断・治療の進歩ー」,pp327-331.
15. 古屋 茂樹 (2012) ホスホセリンアミノトランスフェラーゼ欠損症. 別冊 日本臨牀 新領域別症候群シリーズ No.19「先天代謝異常症候群(第2版)ー病因・病態研究,診断・治療の進歩ー」,pp332-334.
16. 古屋 茂樹 (2012) ホスホセリンホスファターゼ欠損症. 別冊 日本臨牀 新領域別症候群シリーズ No.19「先天代謝異常症候群(第2版)ー病因・病態研究,診断・治療の進歩ー」,pp335-337.
17. 古屋 茂樹,江崎 加代子 (2012) 大豆タンパク質由来ジペプチドが中枢神経系に及ぼす作用の神経化学的評価,大豆タンパク質研究, 15, 79-84.
18. Esaki, K., Kokido, T., Ohmori, T., Tsukino, M., Ohshima, T., Furuya, S. (2011) Soy peptide ingestion increases neuroactive amino acids in the adult brain of wild-type and genetically engineered serine-deficient mice. J. Nutr. Food Sci. 1, 109. doi:?10.4172/2155-9600.100010
19. 古屋 茂樹 (2011) セリン合成不全によるスフィンゴ脂質恒常性破綻と末梢神経障害・糖尿病関連病態. アミノ酸研究,5, 15-20.
20. Yang, JH., Wada, A., Yoshida, K., Miyoshi, Y., Sayano, T., Esaki, K., Kinoshita, O.M., Tomonaga, S., Azuma, N., Watanabe, M., Hamase, K., Zaitsu, K., Machida, T., Messing, A., Itohara, S., Hirabayashi, Y., Furuya, S. (2010) Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an NMDA receptor co-agonist, in adult brain. J. Biol. Chem. 285, 41380-41390.
21. 古屋 茂樹 (2010) 遺伝性セリン合成不全疾患モデルマウスの脳内遊離アミノ酸組成に及ぼす大豆ペプチド摂取効果の定量的検討, 大豆タンパク質研究, 13, 109-115.
22. 古屋 茂樹 (2010) アミノ酸研究の最前線I. 外科と代謝・栄養, 44, 65-71.
23. Kinoshita, O.M., Shinoda, Y., Sakai, K., Hashikawa, T., Watanabe, M., Machida, T., Hirabayashi, Y., Furuya, S. (2009) Selective up-regulation of 3-phosphoglycerate dehydrogenase (Phgdh) expression in adult subventricular zone neurogenic niche. Neurosci. Lett. 453, 21-26.
24. Kinoshita, O.M., Furuya, S., Ito, S., Shinoda, Y., Yamazaki, Y., Greimel, P., Ito, Y., Hashikawa, T., Machida, T., Nagatsuka, Y., Hirabayashi, Y. (2009) Lipid rafts enriched in phosphatidylglucoside direct astroglial differentiation by regulating tyrosine kinase activity of EGF receptors. Biochem. J. 419, 565-575.
25. Kawakami, Y., Yoshida, K., Yang, J.H., Suzuki, T., Azuma, N., Tanaka, H., Watanabe, M., Kuhara, S., Hirabayashi, Y., Furuya, S. (2009) Impaired neurogenesis in the embryonic spinal cord of Phgdh knockout mouse, a serine deficiency disorder model. Neurosci. Res. 63, 184-193.
26. Furuya, S., Yoshida, K., Kawakami,Y., Yang, J-H., Sayano, T., Azuma, N., Tanaka, H., Kuhara, S., Hirabayashi, Y. (2008) Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: Changes in gene expression and associated regulatory networks resulting from serine deficiency. Funct. Integr. Genomics. 8, 235-249.
27. Furuya, S. (2008) An essential role for de novo synthesis of L-serine in CNS development. Asia Pac. J. Clin. Nutr. 17 (S1), 307-310.
28. Hirabayashi, Y., Furuya, S. (2008) Roles of L-serine and sphingolipid synthesis in brain development and neuronal survival. Prog. Lipid Res. 47, 188-203.
29. Ohkawa, N., Fujitani, K., Hinohara, Y., Tokunaga, E., Furuya, S., Inokuchi, K. (2007) Stathmin, a microtubule destabilizer, mediates the development of dendritic arbors in neuronal cells. J. Cell Sci. 120, 1447-1456.
30. 古屋 茂樹 (2007) 第4章脳機能とセリン合成, 「アミノ酸の機能特性 ?ライフサイエンスにおける新しい波-」,日本栄養・食糧学会監修、矢ケ崎一三・門脇基二・舛重正一・横越英彦編集, 建帛社, pp135-169 (2007).
31. 加藤 久典, 林 裕造, 高橋 迪雄, 古屋 茂樹, 岸 恭一, 門脇 基二 (2007) 進化の視点からアミノ酸栄養を考える (論壇). 日本栄養・食糧学会誌, 60, 151-166.
32. 古屋 茂樹 (2006) セリン:脳を育むアミノ酸. 必須アミノ酸研究 (Report of the Research Committee of Essential Amino Acids), 177, 20-27.
33. 古屋 茂樹, 吉田 一之, 平林 義雄 (2006) III編 発現解析と機能解析, 第1章モデル動物 4.マウス, 「DNAチップ活用テクノロジーと応用」, 久原哲編, CMC出版, pp118-130.
34. 古屋 茂樹 (2006) セリンは神経細胞の必須アミノ酸である. バイオサイエンスとインダストリー, 64, 27-29.
35. Satoi, H., Tomimoto, H., Ohtani, R., Kitano, T., Kondo, T., Watanabe, M., Oka, N, Akiguchi, I., Furuya, S., Hirabayashi, Y. Okazaki, T. (2005) Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis. Neuroscience 130, 657-666.
36. Shimizu, M., Furuya, S., Shinoda, Y., Mitoma, J., Okamura, T., Miyoshi, I., Kasai, N., Hirabayashi, Y., and Suzuki, Y. (2004) Functional analysis of mouse 3-phosphoglycerate dehydrogenase (Phgdh) gene promoter in developing brain. J. Neurosci. Res. 76, 623-632.
37. Mitoma, J., Furuya, S., Shimizu, M., Shinoda, Y., Yoshida, K., Azuma, N., Tanaka, H., Suzuki, Y., Hirabayashi, Y. (2004) Mouse 3-phosphoglycerate dehydrogenase gene: Genomic organization, chromosomal localization, and promoter analysis. Gene 334, 15-22.
38. Yamamoto, T., Nishizaki, I., Nukada, T., Kamegaya, E., Furuya, S., Hirabayashi, Y., Ikeda, K., Hata, H., Kobayashi, H., Sora, I., Yamamoto, H. (2004) Functional identification of ASCT1 neutral amino acid transporter as the predominant system for the uptake of L-serine in rat neurons in primary culture. Neurosci Res. 49, 101-111.
39. Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., and Hirabayashi, Y. (2004) Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. J. Biol. Chem. 279, 3573-3577.
40. Furuya, S. and Watanabe, M. (2003) Novel neuroglial and glioglial relationships mediated by L-serine metabolism. Arch. Histol. Cytol. 66, 109-121.
41. Yamashita, N., Sakai, K., Furuya, S., Watanabe, M. (2003) Selective expression of L-serine synthetic enzyme 3PGDH in Schwann cells, perineuronal glia and endoneurial fibroblasts in rat sciatic nerves and its upregulation after crush injury. Arch. Histol. Cytol. 66, 429-436.
42. Chen, P., Peng, C., Luff, J., Spring, K., Watters, D., Bottle, S., Fururya, S., Lavin, M.F. (2003) Oxidative stress is responsible for deficient survival and dendritogenesis in Purkinje neurons from Atm mutant mice. J. Neurosci. 23, 11453-11460.
43. Furuya, S. and Watanabe, M. Novel Neuroglial and Glioglial Relationships Mediated by L-Serine Metabolism. Arch. Histol. Cytol. 66, 109-121 (2003).
44. Chen, N., Furuya, S., Shinoda, Y., Yumoto, M., Ohtake, A., Sato, K., Doi, H., Hashimoto, Y., Kudo, Y., Higashi, H. (2003) Extracellular carbohydrate-signal triggering PKA-dependent neuronal actin-reorganization. Neuroscience 122, 985-995.
45. Yamamoto, T., Nishizaki. I, Furuya, S., Hirabayashi, Y., Takahashi, K., Okuyama, S., Yamamoto, H. (2003) Characterization of rapid and high-affinity uptake of L-serine in neurons and astrocytes in primary culture. FEBS Lett. 548, 69-73.
46. Chen, N., Furuya, S., Doi, H., Hashimoto, Y., Kudo, Y., Higashi, H. (2003) Ganglioside/Calmodulin kinase II signal inducing cdc42-mediated neuronal actin-reorganization. Neuroscience 120, 163-176.
47. Sakai, K., Shimizu, K., Koike, T., Furuya, S, Watanabe, M. (2003) Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J. Neurosci., 23, 550-560.
48. 古屋 茂樹 (2002) グリア細胞による脳の発達支持機構, 脳・神経科学入門講座(下)、第1章 脳の発生と発達6、渡辺雅彦編、羊土社、分担執筆、pp88-101.
49. Yamasaki, M., Yamada, K., Furuya, S, Mitoma, J., Hirabayashi, Y., Watanabe M. (2001) 3-Phosphoglycerate dehydrogenase (3PGDH), a key enzyme for L-serine biosynthesis, is preferentially expressed in the radial glia/astrocyte lineage and olfactory ensheathing glia in the mouse brain. J. Neurosci. 21, 7691-7704.
50. Hartell, N.A., Furuya, S., Jacoby, S., Okada, D. (2001) Intercellular action of nitric oxide increases cyclic GMP in cerebellar Purkinje cells. Neuroreport 12, 25-28.
51. Sugishita, H., Kuwabara Y., Toku K., Doi L., Yang L., Mitoma J., Furuya S., Hirabayashi Y., Maeda N., Sakanaka M., Tanaka J. (2001) L-Serine regulates the activities of microglial cells that express very low level of 3-phosphoglycerate dehydrogenase, an enzyme for L-serine biosynthesis. J. Neurosci. Res., 64, 392-401.
52. Furuya, S., Tabata, T., Mitoma, J., Yamada, K., Yamasaki, M., Makino, A., Yamamoto, T., Watanabe, M., Kano, M., Hirabayashi, Y. (2000) L-Serine and glycine serve as major astroglia-derived trophic factors for cerebellar Purkinje neurons. Proc. Natl. Acad. Sci. USA 97, 11528-11533.


生物機能デザイン研究室

〒812-8581 
福岡市東区箱崎6丁目10-1 
旧工学部3号館
       315,316,317,319号室
TEL /FAX : 092-642-7604
Email: shigekifur(アットマーク)brs.kyushu-u.ac.jp

Room #315, 3rd Building of Engineering School. 6-10-1 Hakozaki, Higashiku, Fukuoka 812-8581, Japan
Tel/Fax: +81-92-642-7604
Email: shigekifur(アットマーク)brs.kyushu-u.ac.jp

所属組織

○研究組織
1.研究院  
  農学研究院 生命機能科学部門  
  システム生物工学講座
2.研究センター  
  バイオアーキテクチャーセンター
  機能デザイン部門(複担)

○教育組織
1.学部  
  農学部 応用生物科学コース
  食糧化学工学分野
2.大学院(修士・博士)  
  生物資源環境科学府
  生命機能科学専攻
  システム生物学教育コース(修士)
 生物産業創成専攻 機能デザイン教
  育コース(博士)


Laboratory of Functional Genomics and Metabolism,
Division of Systems Bioengineering, Department of Bioscience and Biotechnology,
Graduate School of Bioresource and Bioenvironmental Sciences,
Kyushu University